Niacin

INGREDIENTS

Niacin, also known as vitamin B3 or nicotinic acid, supports more than 500 enzymatic reactions that play pivotal roles in metabolism, energy production, and healthy aging. Time-release Niacin with niaxtend provides a considerable amount of nicotinic acid combined with a proprietary wax-coated technology to yield an 8-hour extended-release tablet that greatly reduces the chance of experiencing the uncomfortable skin flushing that commonly accompanies brands of this vitamin that don’t feature a timed-release mechanism.

BENEFITS

• Supports cardiovascular health*
• Extended-release formula decreases chance of “Skin Flushing”*
• Supports the maintenance of cognitive function with age*
• Supports healthy metabolism & energy production within the body*

EXTENDED BENEFITS

Supports cardiovascular health

*Extensive clinical research has shown that niacin as nicotinic acid may promote a favorable balance of blood lipids. The form of niacin typically found in multivitamins and fortified foods is “nicotinamide,” which exhibits vitamin B3 activity but not (the word “necessarily” has been removed) the cardiovascular benefits seen in research that examined nicotinic acid. According to a report endorsed by the American Heart Association, nicotinic acid appears capable of modulating blood lipids in part by altering their synthesis and inhibiting the mobilization of free fatty acids.1 Two niacin receptors, HM74 & HM74A, were recently discovered in humans. The HM74A receptors on adipose (fat) cells are believed to be particularly responsible for the helpful blood lipid-altering ability of nicotinic acid.2*

Extended-release Formula

Decreases chance of “Skin Flushing”

*Sustained-release Niacin with niaXtend® provides an 8-hour extend release tablet that enables more people to access the health-supportive aspects of niacin with less chance of experiencing the uncomfortable skin flushing that commonly accompanies (“the unspecialized niacin in” has been removed) immediate-release (IR) forms of the vitamin. Release of the eicosanoid prostaglandin D2 from skin cells is believed to be behind the skin flushing that may occur with niacin use. This “prickly heat” phenomenon results in a sensation of warmth, reddening, and/or tingling anywhere from 15 to 120 minutes after consumption of a large dose, often felt on the head, neck, and shoulders for up to an hour. Although flushing is a non-allergic reaction producing no permanent harm to the body, it is the major reason for discontinued use of niacin—thereby preventing many individuals from experiencing the potential benefits of supplementation. When taken as directed, extended-release formulas similar to Sustained-release Niacin with niaXtendhave been shown to decrease the potential of flushing.3,4

Supports the maintenance of cognitive function with age

*Diets high in niacin have been associated with healthy cognitive function in the aging mind. This may in part be a result of niacin’s direct role in the regulation of healthy dendritic growth; dendrites are a class of neuronal cells that enable the brain to communicate electric signals to other parts of the brain and the body. Niacin is able to provide potent antioxidant activity to address the accumulation of free radicals in brain mitochondria, the powerhouse organelles within neurons. Niacin is important for many of the complex regulatory pathways utilized by the body to maintain health with age.

Supplement Facts

Serving Size 1 Tablet
Servings Per Container 120
Amount Per Serving % Daily Value
Niacin (as nicotinic acid) 500 mg 3125%
Daily Value not established.

Other Ingredients : Vegetable waxes (rice bran and/or carnauba wax), stearic acid, magnesium stearate (vegetable source), sil ica.

Suggested Adult Use : As a dietary supplement, take 1 tablet daily with food, or as recommended by a nutritionally- informed physician.

WARNING : If you are pregnant, nursing, have a medical condition, or taking medication, consult your physician before itching or redness of the skin, are common side effects that may occur upon initial use. These effects may worsen if you drink alcohol or hot beverages shortly after taking niacin. Do not take more than 500 mg per day (one tablet) except under the supervision of a physician. Liver damage and jaundice are risks with high doses of niacin. Avoid high doses of niacin if you have a liver or kidney disorder.

Non-GMO / Gluten Free / Vegan

Store in a cool dry place.niaXtend® is a registered trademark of Endurance Products Co.

Supports healthy metabolism & energy production within the body

Niacin—in both its nicotinic acid and nicotinamide forms—is well absorbed and can act as a biochemical precursor to nicotinamide adenine dinucleotide (NAD+) and sister coenzyme nicotinamide adenine dinucleotide phosphate (NADP+). The two molecules NAD+ and NADP+ are involved in more than 500 enzymatic reactions and are especially important in metabolism and energy production. All of the human body’s cellular energy is synthesized through mitochondrial oxidative phosphorylation, the citric acid cycle, and cytosolic glycolysis: these pathways all require an adequate supply of NAD+ and NADP+.6

Sustained-Release Niacin with niaXtend supplies nicotinic acid in an extended-release form that supports healthy metabolism and energy production throughout the day by helping to provide the body with an abundant pool of NAD+ and NADP+.

SAFETY

Niacin is a safe and effective supplement if taken as directed by the label or your physician.4 If you are currently taking statins or other medications, have gout or liver dysfunction, or are otherwise under medical supervision, consult your physician before starting niacin supplementation.